The building occupied by the museum is the main house of one of the city's merchant estates of the late 18th and early 20th centuries. From 1835 to 1917, the estate belonged to generations of Kekin merchants, in 1918 it was nationalized and given over to an agricultural college. In 1999, the main house of the estate was transferred to the museum. On August 29, 2008, after the restoration was completed, the Museum of Rostov Merchants was opened here.
The exhibition "Kekins – family, destiny, heritage" tells about the Kekin family, using his example about the history and culture of the Rostov merchants, the genealogy of local merchant families. The interiors of the rooms have been recreated: living room, boudoir, dining room, study. Objects, documents, picturesque portraits and photographs of representatives of the Kekin family are presented. The exhibits characterize the everyday life, commercial and social activities, spiritual and material culture of the merchant class.
Part of the halls of the house is used for temporary exhibitions.